Denosyl, Marin and Milk Thistle

ok so I said I was going to do a post about these 3 supplements I haven't had the chance to do a whole lot of research on them, but I'm just going to post basic information here. I will do a more detailed most in the days to come. First Denosyl has been basically prescribed by my Vet for Lola to take 1 full pill a day even with her 5.5lb body here's a description of Denosyl.

Brand Name
Denosyl (Nutramax)

Active Ingredient(s):
S-Adenosylmethionine

What is this product used for:
Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects liver cells from toxins and death. Denosyl is recommended to improve hepatic glutathione levels in compromised animals to help maintain and protect liver function.

Availability:
Denosyl is a non-prescription (OTC) product available as 90mg, 225mg and 425mg stabilized tablets.

How this product should be used:
The tablets should be given on an empty stomach at least one hour before feeding. Research shows that, if possible, a fasting period of 8-12 hours before giving this product is optimal. The usual dose in cats and dogs is based on weight. For pets up to 12 lbs give 1 tablet of the 90mg strength, for pets 13 to 34 lbs give 1 tablet of the 225mg strength, for pets 35 to 65 lbs give 1 tablet of the 425mg strength, for pets 66 to 120 lbs give 2 tablets of the 425mg strength and for pets over 120 lbs give 3 tablets of the 425mg strength. When giving more than 1 tablet the total number of tablets may be divided into morning and evening. For example, a dose of 3 tablets could be divided into 2 tablets in the morning and 1 tablet in the evening.

What are the side effects:
There are no reported side effects.

What special precautions are there:
Tablets must be given whole. Do not break or split. Research shows that this product may be of benefit to pets that are also taking primidone, Phenobarbital, prednisone, azathioprine, cyclosporine and certain anti-depressants.

In the event of overdose:
Contact a veterinarian or veterinary emergency room.

How should I store this product:
Store this product in a cool, dry, place. Keep tablets in the original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. Keep out of the reach of children.

This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet.

The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.

Note: Any trademarks are the property of their respective companies

Ok this was taken right off of Petmeds.com so I haven't researched any of the claims, but it gives a basic overview. it says to fast for 8-12 hours I'll be honest and say Lola doesn't really fast for that long I just try to give it to her when she hasn't eaten in awhile this may be something I need to change, but I'm gonna talk to my vet about this again soon.

The Second Supplement Lola was prescribed by the vet is Marin and Lola takes 1/4 of a pill once a day. here's the description of this stuff.

Brand Name
Marin for Dogs (Nutramax)

Active Ingredient(s):
Marin for Large Dogs; Vitamin E (300 IU), Silybin A+B (70 mg), Zinc (45 mg)

Marin for Small to Medium Dogs: Vitamin E (105 IU), Silybin A+B (24 mg), Zinc (17 mg)

What is this product used for:
Marin for Dogs is specially formulated with silybin, vitamin E and Zinc to provide a multifaceted approach to liver support. Silybin is the most biologically active component of an extract known as silymarin. Silybin/sylimarin has been shown to have beneficial effects on liver function. Vitamin E, a membrane-associated antioxidant, helps protect the liver against oxidant injury. Zinc, an essential trace mineral and component of approximately 200 enzymes participates in protein and carbohydrate metabolism and hormone synthesis, in the liver and throughout the body. Studies have shown that silybin/silymarin protects against oxidative stress, provides a mechanism for liver cell regeneration, inhibits leukotrienes which are a component of the inflammatory response, stimulates biliary flow and production of hepatoprotective bile salts and increases levels of glutathione.

Availability:
Marin for Large Dogs and Marin for Small to Medium Dogs are non-prescription (OTC) products. The tablets are scored for ease of administration.

How this product should be used:
The recommended dose of Marin for Large dogs in dogs up to 36-54 lbs is 1/2 tablet daily. For dogs 55-99 lbs give 1 tablet daily and for dogs over 100 lbs give 1 ½ tablets daily. Give on a full stomach.

The recommended dose of Marin for Small to Medium Dogs under 10 lbs is 1/4 tablet daily. For dogs 11-19 lbs give 1/2 tablet daily, and for dogs 20-35 lbs give 1 tablet daily. Give on a full stomach.

What are the side effects:
There are no known side effects.

What special precautions are there:
This product is for veterinary use in dogs only.

In the event of overdose:
Contact your veterinarian or veterinary emergency room.

How should I store this product:
Store in a cool, dry area out of direct sunlight. Keep lid tightly closed to ensure freshness. Keep out of the reach of children.

This information sheet is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. The information is NOT to be used for diagnosis or treatment of your pet. You should always consult your own veterinarian for specific advice concerning the treatment of your pet.

The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian.

Note: Any trademarks are the property of their respective companies

Again the Above information is taken directly from petmeds.com Lola has been taking this since June and it says it has Milk thistle in it which I'm just realizing I didn't realize til now so more research is needed on this.

The Third Supplement I give Lola is Milk Thistle and I started her on this myself, but several vets and vet techs and Lola's vet clinic said it was very good so that's why I started her on it I server her the Liver Cleanse Diet and I mix some powdered Milk Thistle in it to give her the dose one Human pill of Milk Thistle Lasts Lola over a week I don't give her much as of yet anyway, but here's a description of What exactly Milk Thistle is.

Health benefits

Milk thistle has been reported to have protective effects on the liver and to greatly improve its function. It is typically used to treat liver cirrhosis, chronic hepatitis (liver inflammation), and gallbladder disorders. The active compound in Milk thistle is silymarin, a mixture of at least 4 closely related flavonolignans, 60% to 70% of which is a mixture of 2 diastereomers of silybin. Silymarin is typically administered in amount ranging from 200-500mg per day. Whether or not these dosages are optimal is not known; no scientific data on which to base effective dosage level guidelines is available.

Research into the biological activity of silymarin and its possible medical uses has been conducted in many countries since the 1970s, but the quality of the research has been uneven.[1]

Reviews of the literature covering clinical studies of silymarin vary in their conclusions. A review using only studies with both double-blind and placebo protocols concluded that milk thistle and its derivatives "does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases."[2] A different review of the literature, performed for the U. S. Department of Health and Human Services, found that, while there is strong evidence of legitimate medical benefits, the studies done to date are of such uneven design and quality that no firm conclusions about degrees of effectiveness for specific conditions or appropriate dosage can yet be made. [3]

A review of studies of silymarin and liver disease which are available on the web shows an interesting pattern in that studies which tested low dosages of silymarin concluded that silymarin was ineffective[4], while studies which used significantly larger doses concluded that silymarin was biologically active and had therapeutic effects.[5]

Beside benefits for liver disease and treatment claims include:

* Used as a post cycle therapy for body builders
* Lowering cholesterol levels
* Reducing insulin resistance in people with type 2 diabetes who also have cirrhosis
* Reducing the growth of cancer cells in breast, cervical, and prostate cancers.[6]
* Used in many products claiming to reduce the effects of a hangover

Ok now this info I got off of Wikipedia I have seen Milk Thistle Recommended over and over again for Lola's problems so that's why I'm using that again this does require more research as well which I will post again and also about any changes she's experiencing on these supplements and if the vet recommends any new supplements I may be taking her to a holistic vet soon to if and when I do I will post about it here.